MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region.
Signaling Peptide
Studied as a mitochondrial signaling peptide involved in communication between mitochondria and the nucleus. Research sometimes describes it as a mitochondrial hormone or an exercise mimetic; these terms describe research concepts, not established benefits of this product.
Amino Acid Sequence
MRWQEMGYIFYPRKLR — 16 amino acids. The first 11 residues have been reported as highly conserved across mammalian species.
Metabolic Stress & AMPK
In experimental cell models, MOTS-c can move into the nucleus during metabolic stress and influence gene expression through AMPK-dependent signaling. Research examines glucose handling, lipid metabolism, and cellular energy regulation.
Exercise & Aging Research
Studies have reported increases in endogenous MOTS-c after exercise and age-related differences in its levels. Findings vary by tissue and study population; they do not establish that this research vial reproduces exercise or reverses aging in people.
For laboratory research only. Not for human consumption or medical use.